Prostatic intraepithelial neoplasia- the story evolves
نویسندگان
چکیده
منابع مشابه
High-Grade Prostatic Intraepithelial Neoplasia
High-grade prostatic intraepithelial neoplasia (HGPIN) has been established as a precursor to prostatic adenocarcinoma. HGPIN shares many morphological, genetic, and molecular signatures with prostate cancer. Its predictive value for the development of future adenocarcinoma during the prostate-specific antigen screening era has decreased, mostly owing to the increase in prostate biopsy cores. N...
متن کاملBiologic markers in prostatic intraepithelial neoplasia: immunohistochemical and cytogenetic analyses.
OBJECTIVE We evaluated the biological properties of High-grade prostatic intraepithelial neoplasia (PIN) by immunohistochemistry and fluorescence in situ hybridization (FISH) analysis in relation to normal tissue and carcinoma lesions. MATERIALS AND METHODS Immunohistochemical staining and FISH were performed on 23 formalin-fixed radical prostatectomy specimens taken from patients with PIN. A...
متن کاملA basal cell defect promotes budding of prostatic intraepithelial neoplasia.
Basal cells in a simple secretory epithelium adhere to the extracellular matrix (ECM), providing contextual cues for ordered repopulation of the luminal cell layer. Early high-grade prostatic intraepithelial neoplasia (HG-PIN) tissue has enlarged nuclei and nucleoli, luminal layer expansion and genomic instability. Additional HG-PIN markers include loss of α6β4 integrin or its ligand laminin-33...
متن کاملFrequency of high-grade prostatic intraepithelial neoplasia in Mexican population.
BACKGROUND High-grade intraepithelial neoplasia (HGPIN) is the only lesion regarded as precursor of prostatic carcinoma, though its frequency is unknown in many countries. Here we studied the frequency of HGPIN in a population with high grade frequency of prostatic carcinoma. MATERIAL AND METHODS A total of 486 cases of sextant prostatic biopsies performed from January 2001 to January 2006 we...
متن کاملConstruction of a representative cDNA library from prostatic intraepithelial neoplasia.
We report the construction of a plasmid-based cDNA library made from microdissected cells derived from prostatic intraepithelial neoplasia. Total RNA was extracted and converted to blunt-ended, double-stranded cDNA by oligo(dT)-mediated reverse transcription followed by linker addition. A linker-specific primer with UDG-compatible ends was used to amplify the cDNA and the resulting PCR product ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Pathology of Nepal
سال: 2016
ISSN: 2091-0908,2091-0797
DOI: 10.3126/jpn.v6i12.16258